Natural Approaches to Adrenal and Cortisol Health

Adrenal Gland Fatigue: Adrenal gland fatigue is a popular term used to describe a theoretic condition where the adrenal glands excrete too much cortisol when under prolonged stress, leading to a cortisol deficiency. It is important to note that while this term is often heard, adrenal gland fatigue is not a medically accepted condition due to the lack of evidence that it exists. In this article, we discuss more natural adrenal supplements in detail.
natural adrenal supplements
Natural adrenal supplements

Natural Adrenal Supplements

The adrenal gland plays an important function in maintaining and regulating essential hormones. (1) These hormones include helping your body to burn fat and protein, managing blood sugar levels, stress levels, and blood pressure. (3) These supplements help with many natural physiological functions such as the metabolism of neurotransmitters like dopamine and norepinephrine, increasing energy levels, and controlling cortisol response. (2) However, lifestyle management alone may not be enough to reverse adrenal fatigue. Therefore, some individuals may want to take natural adrenal supplements in addition to partaking in healthy lifestyle interventions.

Adrenal Balance Supplements

The body has a natural response system to combat stress. There are wide groups of hormones and neurotransmitters that are essential to respond to physical and psychological stresses. However, when the body cannot keep up with the stress responses of the body, a condition of adrenal insufficiency occurs. (2) There are three types of adrenal insufficiency: primary, secondary, and tertiary. Adrenal fatigue can develop gradually over time and can be caused by consistently high levels of cortisol. (4) Fortunately, adrenal fatigue can be reversible to some degree. natural adrenal supplements can be used in conjunction with lifestyle modifications for reducing high levels of cortisol and symptoms of fatigue.


Adrenal Dietary Supplement

When there are high stressors affecting the body, cortisol levels increase. This response in cortisol levels is due to adrenal glands. Infections, tumors, autoimmune disorders, and other diseases can affect the adrenal glands. (5) A contributing factor to high cortisol levels is low blood sugar levels or hypoglycemia. (2) Small, frequent meals with minimized simple carbohydrate consumption are recommended to reduce episodes of hypoglycemia. Some patients incorporate an adrenal dietary supplement to help manage symptoms of adrenal fatigue. An example is licorice, which may work alongside cortisol. People think Licorice binds to the same receptors as cortisol. (2)

 
Adrenal Complex Supplement

The adrenal gland is made up of the cortex and adrenal medulla. (2) The cortex makes up most of the adrenal gland compared to the adrenal medulla. The cortex is further divided up into three layers: the glomerulosa, fasciculata, and reticular. Each layer of the cortex secrets different hormones including aldosterone, cortisol, and androgens. The adrenal medulla secretes epinephrine and norepinephrine. These hormones are involved with the body’s sympathetic nervous system’s natural flight or fight response. To aid in hormone management, natural adrenal supplements can be added to one’s diet as part of integrative therapy.


Taking Adrenal Supplements

Taking adrenal supplements or natural adrenal supplements is an option for patients that experience fatigue, difficulty with morning waking, low blood sugars, and are prone to infections. However, there can be more symptoms with adrenal gland concerns. A few supplements to combat these symptoms are vitamin B complex, vitamin C, L-Carnitine, dehydroepiandrosterone (DHEA), and adrenal glandular. Though, there is minimal evidence for the safety and effectiveness of using DHEA and adrenal glandular compared to the other supplements. (2) These natural adrenal supplements may be helpful in improving energy and metabolism. The vitamin B complex specifically has protective nutrients for the adrenals, as shown through studies. (2)


Adrenal Stress Supplement

There is more than one natural adrenal supplement for stress which supports adrenal health. One supplement is L-Carnitine. (2) It is a supplement that may be used for improving metabolism and energy. It works through moving fatty acids into the mitochondria, which is an organelle in the cell that makes energy. Specifically, in elderly adults, a randomized controlled trial showed a significant decrease in fat and an increase in muscle. (10) Results indicated that there were increases in physical and cognitive abilities through the supplement’s mechanism of action. (10)


Adrenal cortex supplement


Addison’s disease affects as many as 144 million people in the world; however, the epidemiology in children is inconclusive. (11) Addison’s disease results from reduced cortisol production. There are diverse contributing factors of adrenal insufficiency, with no specific population that is at increased risk. An adrenal cortex supplement may contribute to improving symptoms of adrenal insufficiency. Symptoms include altered mental status, weight loss, fatigue, reproductive complaints like amenorrhea in women, and skin discoloration. (11) However, these symptoms are nonspecific and can be difficult to diagnose.

Adrenal herbal supplements

Some suggest that a few herbal or natural adrenal supplements can support healthy adrenal glands. The following are some examples; Glycyrrhiza licorice powdered root, Ashwagandha powdered herb, Panax ginseng dried root powder, and Rhodiola Rosea. (2) People suggest that licorice works by binding to similar receptors as cortisol, mimicking the effects of the hormone. Ashwagandha works by reducing biological changes that result from severe stress. Panax ginseng aids corticosteroids to bind their receptors. Rhodiola Rosea contains properties related to central nervous system activities to regulate levels of natural neurotransmitters in the body.

Adrenal response supplement

The adrenal glands are responsible for the maintenance and regulation of hormones regarding the body’s natural homeostasis process. There have been studies regarding an adrenal response supplement to aid in the health of the adrenal glands. (2) Natural supplements include licorice, ashwagandha, ginseng, and Rhodiola Rosea. (2) Supplements are dosed daily, but there are precautions when taking these supplements. These precautions are side effects such as dry mouth and dizziness when taking Rhodiola Rosea and insomnia when taking ginseng. Though, some natural adrenal supplements are well tolerated. (2)

Adrenal insufficiency supplements

Adrenal insufficiency is a complicated diagnosis and is defined as a life-threatening disorder that can result from hypothalamic-pituitary axis impairment. (12) It can result from an autoimmune disorder or a deficiency in hormones that are necessary for survival. Reasons for the deficiency may vary from primary adrenal failure, secondary adrenal disease, or tertiary adrenal insufficiency. (12) Each is classified according to the contributing factor for the disease. To support adrenal gland health and hormone regulation, natural adrenal supplements have been proposed.

Adrenal glandular supplements

Adrenal glandular supplements are supplements that are derived from the adrenal glands of animals. They are often ground-up and can include cortisol and catecholamines. (2) However, there is inconclusive data regarding the safety and efficacy of the supplements. With long-term use, there could be potential for harm because there is no consistent dose in each adrenal glandular supplement. As a result, natural adrenal supplements are not recommended as they may suppress the body’s normal and natural regulation process. (2)

Adrenal support supplements

There are three different classifications of adrenal insufficiency. They include primary, secondary, and tertiary. Primary adrenal insufficiency is mainly due to an autoimmune disorder. The adrenal cortex can be destroyed when this occurs because the body’s antibodies attack itself. Secondary adrenal insufficiency can result from damages to the pituitary. A damaged pituitary can cause nonfunctional hormone regulation. Brain tumors or abrupt steroid medication withdrawal can lead to tertiary adrenal insufficiency. These barriers can lead to decreased hormone sections that are necessary for the body to function. (11)

Adrenal health supplement

An example of an adrenal health supplement or natural adrenal supplement is licorice. Licorice is considered for this health condition because it contains glycyrrhizin and is considered “generally safe” under the U.S. Food and Drug Administration. (13) Consideration must be taken when using this supplement as many manufacturers don’t need to certify the safety or efficacy. In addition, with all supplements and medications, long-term use can produce adverse effects. Some side effects with long-term and high-dose licorice may include high blood pressure, elevated potassium levels, and adrenal hormone disorders. (13)

Adrenal plus supplement

According to the Natural Medicines database, the Adrenal Plus supplement by Futurebiotics LLC has been discontinued. (14) It contained different ingredients such as adrenal concentrate, vitamin C, pantothenic acid, zinc, manganese, schizandra, Chinese licorice, niacinamide, and licorice. All of these ingredients also had specific dosages. However, the manufacturer decided to discontinue the supplement. The safety and effectiveness of the supplement are inconclusive, as supplements do not have stringent policies to prove their labeling. (13,14) With all-natural adrenal supplements and medications, there may be adverse effects that patients can experience.

Natural supplements for adrenal fatigue

There are natural adrenal supplements for adrenal fatigue, although it is a controversial diagnosis from an allopathic medicine point of view. (7) A more acceptable diagnosis for those experiencing adrenal fatigue symptoms is adrenal insufficiency. Symptoms of adrenal insufficiency are nonspecific, making the diagnosis more difficult for providers. A common intervention for this disease is lifestyle modification. A few examples are incorporating exercise, stress relief techniques, and a healthier diet. (2) The main takeaway from this diagnosis is to minimize stress and live a healthier lifestyle.

Adrenal fatigue supplements

Adrenal fatigue is used to describe symptoms that patients may experience when they have chronic stress. Supplements adrenal fatigue or natural adrenal supplements may be offered because reported treatments for adrenal fatigue may be expensive. Many insurance companies may not cover the costs. (4) Adrenal fatigue results from the body not being able to manage long-term stress or stressful situations, leading to dysregulation of hormones such as cortisol. When this occurs, nonspecific symptoms may arise such as tiredness and trouble sleeping.4

Supplements to help adrenal fatigue

There may be natural adrenal supplements to help adrenal fatigue. However, extra precautions must be taken into consideration before claiming its effectiveness or safety. (4) Although the U.S. Food and Drug Administration plays a role in medication manufacture, supplements and vitamins are not looked at closely. Potential harm when taking long-term supplements and vitamins may be hormone dysregulation which can lead to an adrenal crisis. (4) An adrenal crisis is life-threatening and should not be taken lightly.

Supplements for extreme fatigue

A common nonspecific symptom of many diseases and disorders is fatigue. Fatigue is extreme tiredness that can affect everyday life. Due to its delayed diagnosis, adrenal insufficiency is considered a rare disease. (15) However, it can be detrimental to one’s survival if it is overlooked. Therapeutic options once diagnosed include glucocorticoid-replacement and mineralocorticoid-replacement therapy. Recently, dehydroepiandrosterone-replacement therapy has also been offered for this diagnosis. (15) Furthermore, there may be natural adrenal supplements for extreme fatigue, but the therapies mentioned are based on clinical decisions.

Adrenal fatigue support supplement

Adrenal insufficiency, once diagnosed, has varying options for therapy. One option is glucocorticoid replacement that is administered with the natural cortisol-secretion pattern. (16) A second option is mineralocorticoid replacement and is only given when primary adrenal insufficiency has been determined. A third option is dehydroepiandrosterone replacement and it is considered optional for adrenal insufficiency. (16) For a more holistic approach to adrenal gland health, an adrenal fatigue support supplement or any natural adrenal supplements may be considered after discussing its potential with a primary care provider.

Herbal supplements for adrenal fatigue

There are clinical and holistic approaches to addressing adrenal gland health and disorders. For individuals seeking a holistic approach, there may be herbal supplements or natural adrenal supplements for adrenal fatigue. Botanicals may include licorice, ashwagandha, ginseng, or Rhodiola Rosea. (2) For diets, there are no salt restrictions, but simple carbohydrate intake should be reduced to avoid low blood sugars. (2) Many mind-body techniques may also be incorporated into everyday life to help in managing and reducing cortisol levels in the body; thus, reducing overall stress.

Adrenal exhaustion supplements

Cortisol production follows a natural circadian rhythm. Cortisol levels usually fall during nighttime during sleep and peak before waking up. (17) Cortisol is important for the body because it helps maintain and regulate stress levels in order to restore the body’s homeostasis process. When stress levels rise too high for a long period of time, its effects can be harmful to the body, leading to symptoms such as extreme tiredness. To help combat these effects or aid with adrenal and cortisol health, adrenal exhaustion supplements or any natural adrenal supplements may be taken into consideration.

Adrenal energy supplement

Dehydroepiandrosterone (DHEA) replacement is a controversial therapy for adrenal insufficiency. (17) It is one of the most prominent circulating steroid hormones in the body. (18) It is a hormone that contributes to anti-aging in animal models. Its mechanism of action involves improving physical and psychological well-being through increasing the number of monocytes, T cells, and natural killer cells in the body. (18) These cells are important for combating many immune-related issues when there are psychological or physiological stressors against the body. DHEA was considered an adrenal energy supplement or any natural adrenal supplement, but there is minimal evidence for its support. (2)

Adrenal boost supplement

L-Carnitine is an example of an adrenal boost supplement or any natural adrenal supplement that plays a role in the body’s natural metabolism process. (19) Specifically, it is involved in fatty acid metabolism and is found in many foods. These include red meats, fish, poultry, and milk. It works by transporting fatty-acid chains to the mitochondria, allowing cells to make use of the broken-down fat and harvest the energy derived from that process. (19) L-Carnitine appears safe, but more studies need to be conducted to determine its effects.


Adrenaline booster supplements

Examples of adrenaline booster supplements or any natural adrenal supplements for adrenal gland health include L-Carnitine, vitamin B complex, and vitamin C. (2) L-Carnitine is a supplement that can boost metabolism, which in turn boosts energy levels. It acts on the functions of the mitochondria, a part of the cell that is involved with energy production. Vitamin B complex is useful for protecting the adrenals and improving sleep quality, important for the production of neurotransmitters. (2) Vitamin C is useful for neurotransmitter metabolism. It is also an important vitamin for the adrenal glands, as it is used the most by them. (2)

Best supplements for adrenal fatigue

Patients with liver diseases oftentimes experience adrenal disturbances. (17) The relationship between these organs suggests a new term called “hepato-adrenal syndrome” due to its effects. Patients experiencing liver disease should be monitored closely for incidences of decreased cortisol levels, which may lead to adrenal insufficiency. (17) These patients may benefit from adrenal insufficiency therapy because exhaustion is likely to result from low lipoprotein levels. However, each patient may benefit from varying therapies with no top medication or the best natural adrenal supplements for adrenal fatigue.

What can i take for adrenal fatigue

For those experiencing symptoms consistent with adrenal gland concerns, a common question that is asked is “what can I take for adrenal fatigue?” Adrenal fatigue is a long-term condition with stress as a contributing factor. (4) A few symptoms include tiredness, trouble sleeping, and salt or sugar cravings. However, there is no test that can diagnose adrenal fatigue. Adrenal fatigue is a controversial topic and supporters suggest a healthy and active lifestyle to combat the effects of internal or external stressors.

What to take for adrenal fatigue

The adrenal glands are important for producing hormones that help maintain homeostasis in the body. However, when the body outwardly expresses distress, there may be problems with the body’s natural homeostasis. Patients experiencing symptoms may wonder what to take for adrenal fatigue. There are natural and therapeutic options that can be recommended by the doctor after appropriate diagnoses and tests have been conducted to address the concerns. There may be other underlying conditions that may contribute to the symptoms.

Adrenal fatigue formula

Adrenal fatigue is a controversial diagnosis from an allopathic perspective. (7) The symptoms that one can experience are tiredness, body aches, weight loss, low blood pressure, dizziness or lightheadedness, body hair loss, and skin discoloration. As a result, there is no one adrenal fatigue formula. Blood tests cannot be used to detect the changes in adrenal function, but your body is sensitive enough to do so. (7) Rather, it is suggested that adrenal fatigue is a mild form of adrenal insufficiency.

Best adrenal supplements

Oftentimes those experiencing extreme tiredness and troubles with sleep seek the best adrenal supplements or any natural adrenal supplements. However, the diagnosis of the disease can be delayed with inadequate treatment. (16) A common medicinal therapy used in adrenal insufficiency is glucocorticoid replacement and is administered in two or three daily doses. Mineralocorticoid replacement therapy is administered as a daily morning dose and usually in the case of primary adrenal insufficiency. (16) These medications are administered to align with the natural rhythm of cortisol levels in the body.

Best adrenal cortex supplement

Acute adrenal crisis can be life-threatening and is considered a medical emergency. (16) Severe hypotension, myopathy, altered mental status, and fever can result from this state. An immediate administration of intravenous hydrocortisone is given to managing the body’s response, followed by a continuous infusion given every 24 hours. (16) Hydrocortisone is a steroid that is involved with managing inflammation. Due to the intense and critical state of an acute adrenal crisis, there is no clinically relevant or best adrenal cortex supplement or any natural adrenal supplements to treat it.

Best adrenal support

There is no one recommendation for the best adrenal support. The adrenal glands are part of the endocrine system, which is responsible for the body’s homeostasis process. (9) The main responsibility of the endocrine system is to produce hormones that act upon the respective tissues or targets. The adrenal cortex helps with regulating specific electrolytes, blood sugars, inflammation, immune response, and other hormones like testosterone. (9) The adrenal glands are so important that they receive one of the highest blood flows. However, a disruption to this natural process can be harmful and produce unwanted effects.

Best adrenal support products

The best adrenal support products involve lifestyle interventions and maintaining a low-stress life. High stress on the body for a long period of time is detrimental to the body and your health. A high rise in cortisol levels may make the body work overtime in order to keep up with the demands. Complications such as adrenal insufficiency can result, but oftentimes high stress can be managed. (2) This can prevent health-related complications from arising and improving quality of life.

Best adrenal support formula

The best adrenal support formula consists of many factors. They can pertain to healthy lifestyle options such as stress relief and improving diet and exercise. For instance, aiming for 7 to 9 hours of sleep a day can improve sleep and overall demeanor. Laughing and laughter therapy is also an option because it releases natural endorphins in the body, which are the “feel-good” neurotransmitters, and reduces stress. (2) Making healthy dietary choices like eating less refined carbs and sugar and limiting alcohol intake helps with improving mood. (2)

Top adrenal supplements

Top adrenal supplements include botanicals and supplements. The theory behind incorporating these supplements into daily life is for managing hormonal levels and protecting adrenal glands’ health. (2) The botanicals are thought to stabilize homeostasis in the body through phytochemicals. Natural supplements may aid in treating adrenal fatigue, but adverse effects must be taken into consideration when planning to use them long term. Supplements such as adrenal glandular and DHEA do not have large evidence in support for their use on adrenal fatigue.2

Best adrenal support supplement

Lifestyle interventions in combination with integrative therapy may be the best adrenal support supplement due to the nonspecific symptoms that adrenal insufficiency presents. The deficiency of hormones such as glucocorticoids and mineralocorticoids contributes to adrenal insufficiency because of its role in hormone management. (11) Treatment is usually aggressive in terms of addressing adrenal failure. However, those undergoing surgery following adrenal insufficiency will need glucocorticoid prophylaxis preoperatively and a dose postoperatively. (11) This is due to increasing cortisol demands due to stress.

Best cortisol supplement

The treatment goals of primary adrenal insufficiency are to avoid adrenal crisis, not over-replacing glucocorticoids or mineralocorticoids, and restoring natural blood pressure. (22) There is no best cortisol supplement, but there are steps that can be taken to help with managing cortisol levels. The main contributor to high cortisol levels is stress. Taking the time to enjoy hobbies and learning stress-reducing techniques are useful for reducing cortisol levels. Specific exercises such as yoga may also be calming for the body.2

Natural cortisol supplement

Thomas Addison described adrenal insufficiency as “weakness, fatigue, anorexia, salt craving, and orthostatic hypotension” in 1855. (17) Adrenal insufficiencies can present as a single disease or in combination with other diseases. Many theories rely on genetic predispositions, but recently, there have been theories in relation to infectious or medication-related contributing factors. (17) Due to its evolving prognosis in the medical field, there may be a natural cortisol supplement that can support adrenal gland health and cortisol production or management.

Cortisol control supplement

Daily physiological cortisol production consists of 5 to 6 mg/m2 of body surface area. (17) Cortisol is directly related to and is considered a biomarker of stress levels. High cortisol levels have been studied to observe its role in increased mortality. Although there is no one cortisol control supplement, there have been suggestions from an allopathic an osteopathic perspective. Production of cortisol expresses a natural circadian rhythm and administration of medications or supplements follow that rhythm to get the body aligned with the patterns. (17)

Cortisol support supplements

Cortisol levels are measured in the body to reflect on information about a patient’s health. (21) Memory and stress are related to cortisol. It was shown in a study that high levels of cortisol are related to poor memory performance and retrieval. (21) However, the intensity of cortisol does not necessarily correlate with the intensity of mental stress. No cortisol support supplements were used in the study but rather measured with the Socially Evaluated Cold Pressor Test vs control procedure. Those reflecting high cortisol levels showed more inconsistent patterns for prospective memory retrieval.

Anti cortisol supplement

The adrenal glands produce a hormone called cortisol under periods of stress, whether internal or external. Some individuals may be interested in an anti-cortisol supplement that helps with the management of cortisol levels. Some adrenal gland disorders due to too much or too little cortisol production are Cushing’s syndrome and Addison’s disease. (1) There are some instances where people are born with a lack of ability of cortisol production, in which this disorder may be genetic or results from another issue in another gland. (1)

Cortisol Reduction Supplements

Those with an adrenal gland disorder concern can take different diagnostic tests for varying hormones or disorders. One such test is the cortisol test. Cortisol is an important hormone that helps with responding to and management of stress, infections, metabolism, blood pressure, and blood sugar. (6) A cortisol test is used to help with the diagnosis of adrenal gland disorders like Cushing’s syndrome or Addison’s disease. It can also be used if someone is experiencing symptoms of an adrenal crisis where cortisol levels are very low. (6) However, the timing of a cortisol test is important because levels fluctuate throughout the day. To help with cortisol management, some people can take cortisol reduction supplements.

Supplement lower cortisol

Adrenal insufficiency is a rare disease, partly due to a delayed diagnosis because of its nonspecific symptoms. (11) A homeopathic option to directly supplement lower cortisol is not explicitly identified. However, there are supplements that can indirectly support adrenal health. An example is Panax ginseng, a type of herbal remedy from Asian culture.23 Ginseng has anti-inflammatory, antioxidant, and anticancer properties. This is beneficial for those suffering from adrenal insufficiency. Cortisol regulates stress levels and is released when the body undergoes stressful mental or physical situations. (11)

Cortisol suppression supplements

There are different cortisol tests that measure the amount of cortisol in the body. The sample source may vary. It was shown that cortisol levels can be assessed from saliva, which is an interesting and convenient sample source. (24) However, it is limited to the free cortisol hormone in the body. With new laboratory and technology innovations, these samples can be used to help address the need for cortisol suppression supplements if there is an excess or reduced amount in the body. (24)

Decrease cortisol supplement

The sympathetic system is involved in regulating the fight or flight response to natural stimuli. When it is activated, an increase in blood pressure and heart rate results from the release of epinephrine, norepinephrine, and cortisol. (2) The activation of the release of these neurotransmitters and hormones causes a diversion of blood towards important organs of the body like the brain, heart, and skeletal muscle. These are important for the survival process when people are faced with a fight or flight situation. In cases where cortisol levels are too high, people may seek a decrease cortisol supplement to help combat its effects.

Natural supplements for fatigue

Fatigue is a common symptom many individuals face during stressful situations. The body becomes tired of all the stressors that it has to fight. Subclinical adrenal fatigue, also known as burnout, may develop when the body is chronically fighting and struggling with the demands of the body over a long period of time. (2) Changes in the levels of neurotransmitters and hormones can contribute to fatigue. This may steer patients towards wanting to seek out resources that may include natural supplements for their symptoms.

Supplements for fatigue and low energy

Supplements for fatigue and low energy may include a vitamin B complex. B vitamins may be used to combat tiredness through their natural role as cofactors in neurotransmitter production. (2) B vitamins are important for energy production and help decrease cortisol hormone release. Through this mechanism, it helps protect the adrenal glands from overworking and overproducing hormones when stressful situations arise, such as an external stimulus. It is considered a daily dose supplement and is safe at regular doses. (2)

Herbal supplements for fatigue

Specific herbal supplements for fatigue such as the Siberian Ginseng have been used in countries to help combat symptoms of adrenal fatigue. Particularly in Russia, the Siberian Ginseng or Eleutherococcus sentidosus have data on its effectiveness. However, most of the information is written in Russian and not available in English. One study from this herbal supplement shows promising results in improving mental and physical performance in athletes. (2) The dosage of this herb is variable and side effects may include cardiovascular effects such as tachycardia and hypertension.

Supplements to help with fatigue

There may be many marketed supplements to help with fatigue, but no directly designated supplement has proven safety and effectiveness for its indication. For instance, some studies for supplements such as vitamin B complex or vitamin C have contributed towards maintaining the body’s natural homeostasis when high cortisol levels have been released. (2) These vitamins like many others are important for the body’s function and survival. Nevertheless, dosing for the vitamins varies between patient populations, specific indications, and daily maximum intake.

Best supplements for fatigue

The best supplements for fatigue are not clearly defined, as most supplements are not thoroughly regulated through the U.S. Food and Drug Administration. (13) However, there are many supplements that can indirectly aid with the processes of cortisol levels. Cortisol is an important hormone that is needed for managing stress. The adrenal glands are responsible for releasing cortisol, which are located above the kidneys. Having too high cortisol levels can be harmful to one’s health and well-being. It can trigger the body’s fight or flight response, developed from evolutionary survival traits.

Supplements for stress and fatigue

There are differential diagnoses for varying adrenal gland disorders and conditions. For example, they include adrenal crisis, adrenal hemorrhage, congenital adrenal hyperplasia, eosinophilia, histoplasmosis, hyperkalemia, sarcoidosis, and tuberculosis. (11) These are important for distinguishing between varying diagnoses with similar nonspecific symptoms. Some supplements for stress and fatigue are on the market, but determining the correct diagnosis is the first step. Knowing the diagnosis is essential for catering to medication therapy instead of applying broad-spectrum medications.

Healing adrenal fatigue

Natural stress-reducing techniques may be beneficial in individuals who suffer from excessive tiredness or seek options for healing adrenal fatigue. For instance, breathing practices and meditation may help calm the body and introduce Zen. Oxidative stress levels in people have correlated with lower cortisol levels. (2) Also, practicing yoga has been shown to decrease illnesses and concerns that are stress-related. Yoga has been shown to increase overall mood and positive well-being. These are a few examples of mind-body interventions that can be incorporated.

Adrenal support vitamins

Adrenal support and overall health are important for maintaining a healthy body. A few adrenal support vitamins are mentioned that may benefit the adrenal glands, but there is inconclusive evidence to prove its safety and effectiveness due to less stringent supplement regulation by the U.S. Food and Drug Administration. (13) Some supplements include vitamin C, vitamin B complex, and L-Carnitine. All are tested for implicitly improving adrenal health through natural effects such as memory improvement, increasing energy levels, and metabolism. (2)

Vitamin c adrenals

The adrenal glands and its mechanism are linked to other organs and tissues in the body. As such, the cofactors that work in each organ or tissue system are similar. Cofactors of vitamin C adrenals are important for cortisol production as shown through one in-vivo study conducted by Kodama et al. (25) There was a relationship between ACTH, cortisol, and vitamin C when an infusion of steroid-free vitamin C was administered for autoimmune disease and allergy treatment. Most of the free vitamin C and cortisol had been removed from circulation.

Vitamins to help adrenal fatigue

Patients with adrenal insufficiency can exhibit symptoms of low blood pressure, altered mental status, weight loss, fatigue, and strange diet cravings for salt. (11) However, patients with adrenal fatigue do not necessarily require salt intake restriction in their diet. Any form of adrenal insufficiency can exhibit low blood pressure. Therefore, holistic approaches such as vitamins to help adrenal fatigue may be useful for patients as an adjunct therapy. Vitamins are important cofactors for maintaining the body’s natural systems.

Best vitamins for stress and fatigue

Obesity and adrenal glands go hand in hand. Obesity is linked to poor diet and exercise, lifestyle interventions that can easily be implemented. The best vitamins for stress and fatigue or even obesity have been suggested to regulate the amount of glucocorticoid being released from the adrenal glands. (26) Specifically, ascorbic acid has been researched to observe if it has beneficial properties for obesity-related mechanisms and excessive fat accumulation. If not taken seriously, obesity can lead to other stress-induced diseases like cardiovascular events or inflammation.

Vitamins for stress and fatigue

The evaluation and diagnosis of adrenal insufficiency is a difficult task as many symptoms are nonspecific. Electrolyte testing and labs for anemia, low sodium, high potassium, and low blood sugars may be conducted, as these values are common for adrenal insufficiency. (11) Serum cortisol levels may also play a role in diagnosing the disease. Vitamins for stress and fatigue to combat some of the symptoms may also be helpful for patients as they are a natural approach.

Vitamins for adrenal fatigue

Adrenal fatigue may be presented as a lesser form of adrenal insufficiency. Although the body is well prepared to handle stress and its effects, chronic stress is very harmful to the body. The body is made up of many systems that work together, whether directly or indirectly handling a response to stimuli. The adrenal glands produce hormones and neurotransmitters that are sent to other parts of the body. This produces a response that may send a signal to another system. One way of aiding the process when chronic stress is introduced may be to use vitamins for adrenal fatigue. (2)

Adrenal health vitamins

Two zones make up the adrenal glands. They are the cortex and medulla. The cortex makes up a larger part of the adrenal glands and is the outside of the glands. The adrenal medulla is situated in the middle of the cortex and makes up a much smaller part of the adrenal glands. Each section in the adrenal glands contributes to the body’s response to stress through either neurotransmitter or steroid hormone production. For example, the cortex produces aldosterone, cortisol, and androgens. Cofactors for the other processes in the body like adrenal health vitamins may also play a role in metabolism. (2)

Best vitamins for adrenal fatigue

Adrenal gland disorders range from genetic mutations, tumors, or other underlying problems. Specifically, in those with Cushing’s syndrome, there is too much cortisol production. Cushing’s syndrome is related to adrenal fatigue through the body’s inability to keep up with the demands of the cortisol hormone and stress. Fortunately, there are lab tests available that can find the cause of Cushing’s syndrome, and treatment can be catered toward it. Adjunctive therapy for the best vitamins for adrenal fatigue or Cushing’s syndrome may not be applicable. (27)

Best vitamins for exhaustion

Causes of Cushing’s syndrome can be due to medications or tumors. When long-term exposure to cortisol is presented due to synthetic medications, Cushing’s syndrome can arise. Oftentimes, synthetic medications that increase cortisol levels are used to treat inflammation for another disease. In addition, specific tumors can produce a hormone that increases cortisol levels. Surgery or another alternative may be needed to remove the tumor. However, with all that is mentioned, Cushing’s syndrome is a rare disorder and the cause can be found through lab tests. (27) A symptom of Cushing’s syndrome is extreme fatigue, so patients may be looking for the best vitamins for exhaustion.

Adrenal vitamins

There are a couple of adrenal vitamins that may help with adrenal gland support. They are vitamin C and vitamin B complex. (2) Vitamin C, also known as ascorbic acid, is useful for many physiological functions such as metabolizing dopamine and norepinephrine. These neurotransmitters are important for energy production and managing stress levels. (2) However, there is a maximum daily dose of vitamin C because the body can only use a certain amount each day. Vitamin B complex is made up of different B vitamins that are important for neurotransmitter production. It gives the body more energy and improves sleep. (2)

Best vitamins for fatigue

Adrenal insufficiency is a disease that involves stress-induced hormones and neurotransmitters. There are no best vitamins for fatigue, but specifically for adrenal insufficiency, there may be a few worth mentioning. People support the use of two vitamins through studies, vitamin B complex and vitamin C. (2) Vitamin B complex is usually dosed as a daily vitamin and helps combat fatigue by improving sleep quality and being cofactors for neurotransmitter production. Vitamin C is usually dosed at 250mg twice daily, but caution must be taken because high doses can cause unwanted side effects such as diarrhea. (2)

B vitamins for adrenal fatigue

There are natural supplements to help combat adrenal gland issues. One example is b vitamins for adrenal fatigue. A common symptom of adrenal fatigue is tiredness. B vitamins provide protective effects for the adrenal glands. They work by reducing the response from stress-related hormone cortisol. (2) There have also been studies that support the use of B vitamins for regulating cortisol, sleep quality, and improving neurotransmitter production. They help with neurotransmitter production through their role as cofactors. Studies were conducted using a daily dose of a B-complex vitamin. (2)

Ashwagandha for adrenals

Ashwagandha is an herb from India known for its natural remedy properties across various diseases. (8) It is especially used as a nervine tonic. It is thought to stabilize cortisol levels and ascorbic acid during stressful situations, as shown in studies regarding rats during swimming endurance tests. (8) It is also effective for cognitive function such that it helps improve memory and energy levels. This is significant because fatigue and reduced mental capacity are common side effects of stress. Stress is physiologically managed through the cortisol hormone.



Minerals for adrenal fatigue

A holistic approach towards adrenal insufficiency includes searches for supplements or minerals for adrenal fatigue. One specific option is ashwagandha, used in Ayurvedic system of medicine for memory and cognitive function. (20) It is thought to be involved in the anti-aging process. In an eight-week study observing the effects of the herb compared against placebo, results were significant. There was an improvement in memory and cognition in patients that took the herb in both short and long-term memory. (20)

Adrenal herbs

There are possible effective adrenal herbs that can be taken. They include ashwagandha and ginseng. (2) Ashwagandha is an Indian herb that has been shown to improve cortisol and blood sugar levels in animal studies. In a small prospective, randomized, double-blind, placebo-controlled study involving 50 adult patients, there was significance in the improvement of memory and cognitive function. (20) Ginseng plays a role in improving physical capability and conditions, as well as stimulating cortisol production for the hypothalamic-pituitary-adrenal axis. (2) However, a side effect of ginseng may be insomnia.

Herbs for adrenal fatigue

Stress is an unavoidable fact of everyday life and is associated with significant morbidity and even mortality. It is postulated that stress may be a contributor to the phenomenon known as adrenal fatigue. Herbs for adrenal fatigue include Panax ginseng, Eleutherococcus senticosus, Withania somnifera, Glycyrrhiza species, and Rhodiola rose. These herbs are considered botanical adaptogens, which are harmless to the host, have a general (a rather nonspecific effect), increase the resistance of the recipient to a variety of physical, chemical, or biological stressors, and acts as a general stabilizer/normalizer. (30)

Best adrenal support herbs

The adrenal glands mobilize the body’s stress responses to each stress, including physical, biochemical, hormonal, thermal, internal, external, emotional, and mental. Special herbs called adaptogens may increase cellular energy levels and prevent stress damage. Adaptogens may influence these factors, leading to the maintenance of normal adrenal function. High stress resulting from improper adrenal function may result in harm leading to fatigue, infection, and depression. Adaptogens lower the body’s response to stress, reduce negative reactions during periods of alarm, and decrease the onset of exhaustion. Some studies show that plant-originated adaptogens are an elite herbal medicine that plays a role in human health to help the body resist various stress factors. (28)

Best herbs for adrenal fatigue

Adrenal fatigue is thought to be influenced by stress. Special herbs called adaptogens are proposed to work by enhancing resistance to stress. The best herbs for adrenal fatigue suggest that Rhodiola Rosea, Schisandra Chinensis, and Eleutherococcus senticosus may be useful to enhance resistance to stress. Some studies suggest that adaptogens provide neuroprotective, anti-fatigue, antidepressive, anxiolytic, nootropic, and CNS stimulating activity in animals or neurons. These herbs may be a new pharmacological category of anti-fatigue drugs that increase attention and endurance in periods of fatigue or weakness and reduce stress impairments during periods of high stress. (29)

Adrenal support herbs

Adaptogens are considered a natural substance that is beneficial in helping the body adapt to stressful circumstances. The effects of adaptogens or natural adrenal support herbs can help the body stabilize its overworked processes. (28) A common herb that is used in Eastern medicines has similar properties as ginseng and can be found worldwide. It is believed to play a role in the immune-neuro-endocrine system and the hypothalamic-pituitary-adrenal axis, both involving hormones and responding to the body’s stress. (28)

Best herbs for adrenals

The best herbs for adrenals may involve adaptogens, which are involved in maintaining stress levels in the body. It was shown in a couple of studies that adaptogens exhibited anti-fatigue effects and improved mental capacity. (29) The positive response of the body to adaptogens has further suggested that they produce stress-protective effects for the neuroendocrine-immune system. The stress-protective effects are connected to the HPA axis, which is involved with homeostasis and is key to the body’s stress response.

Herbs for adrenal health

The use of the medical system in times of stress has drastically increased. (31) Part of using that source is job insecurity, which increases stress levels. Many illnesses incorporate some form of stress, ranging from headaches, immunosuppressive effects, gastrointestinal problems, or cardiovascular disease. There appears to be a correlation between increased stress levels and a decreased immune system. As a result, homeopathic approaches or herbs for adrenal health have been suggested. They may play a role in balancing the body’s immune system and serving a role in treating acute anxiety. (31)

Adrenal support herbal

There may be natural medicines for treating fatigue, including an adrenal support herbal remedy. A couple of forms of fatigue include normal fatigue and pathological fatigue. (32) Normal fatigue is expressed as energy loss, oxidative stress, decrease in glycogen storage, accumulation of metabolites, and increases in normal neurotransmitters like serotonin and dopamine. Pathological fatigue is expressed in the form of inflammation, decreased function of the HPA axis, major side effects from treatments, and alterations in metabolism including muscles. However, fatigue is a common symptom in many diseases, so adrenal diagnoses may be difficult.

Adrenal extract

Life is full of stress which can lead to effects of insomnia, generalized anxiety, cardiovascular diseases, and gastrointestinal diseases. (31) Some of these diseases may be reversible, but only when early recognition of the symptoms is present. There is no specific adrenal extract to combat the effects of stress, but natural botanicals, supplements, and lifestyle considerations can be implemented in daily routines. Stress is unavoidable and any attempts to reduce its effects on the body can help with reducing overall morbidity and mortality.

B complex for adrenal fatigue

Niacinamide, also known as vitamin B3, is a B vitamin that may be helpful for sleep quality. Small studies that included the use of niacinamide for three weeks concluded that there was a significant increase in REM sleep. Pantethine or vitamin B5 may be useful in stimulating ACTH, helping to decrease the release of vast amounts of cortisol in the body under stressful circumstances. A B-complex for adrenal fatigue may be useful for patients seeking improved sleep quality and adrenal cortex function. (31)

Adrenal exhaustion remedy

Fatigue is a common symptom in many diseases across a wide range of mild or serious states. For instance, those with HIV or AIDS or the common cold may suffer from extreme fatigue. Due to its nonspecific symptom, there is no official recommendation or adrenal exhaustion remedy for those suffering from fatigue. (32) Those experiencing the symptom may be informed of the adrenal glands and their role in stress management. A form of pathological fatigue includes inflammation, changes in muscle metabolism, hypofunction of the HPA axis, and side effects. (32)

Homeopathic remedy for adrenal fatigue

The physiology of stress is presented as the initial release of norepinephrine and epinephrine from the adrenal glands into the bloodstream. This activates the body’s fight or flight response system and its adaptation to a stressful situation. Some health consequences that can arise from chronic stimulation of the fight or flight response can lead to cardiovascular disease, bad mood, and other effects. (31) In an attempt to alleviate these symptoms and reduce stress levels, a homeopathic remedy for adrenal fatigue has been suggested. (31)

Herbal remedies for adrenal fatigue

Herbal remedies for adrenal fatigue include botanicals such as adrenal or central nervous system adaptogens. (31) These adaptogens help with biological stressors and encourage stress recovery. For example, Korean ginseng has a great deal of research that shows its response to physical and mental stress in animal studies. There were anti-stress mechanisms on the HPA axis and adrenal glands that were displayed. (31) However, human studies and its use of Korean ginseng is limited, so information on the botanical must be taken cautiously.

Natural remedies for adrenal fatigue

Adrenal fatigue is a controversial topic that is often underdiagnosed. Supporters of the diagnosis claim that patients suffer from adrenal fatigue when there are suppressed adrenal glands due to chronic stressors. (30) Some nonspecific symptoms of the disorder include trouble sleeping, fatigue, weight fluctuation, and many more. A contributing factor towards the difficulty of diagnosing the disorder is the methods for assessing the hypothalamic-pituitary-adrenal axis. Due to this nature, patients seek natural remedies for adrenal fatigue.

Adrenal fatigue remedies

Adrenal fatigue remedies include administering ascorbic acid or vitamin C. Ascorbic acid is an essential cofactor for neurotransmitter production. It was shown in lung cancer patients that appropriate administration of increased vitamin C levels helped improve adrenal health under periods of surgical stress through stabilizing cortisol and ACTH concentrations. Vitamin C was given in strengths of 1 gram three times a day by mouth. However, increased vitamin C levels had no difference in their effects on fasting cortisol levels. (31)

Adrenal insufficiency natural treatment

Adrenal insufficiency, compared to adrenal fatigue, is a well-documented and accepted diagnosis for adrenal glands conditions. It is believed to result from high cortisol levels, which may reduce the responsiveness of the pituitary and adrenal glands. (2) Changes in the HPA axis may be due to several reasons, but many involve modifications in receptor sensitivity or actual cortisol production and release. There is no one adrenal insufficiency natural treatment, but studies have been conducted to present options that indirectly affect the body’s response to stress. (2)

Adrenal fatigue natural treatment

Current evidence does not support the existence of adrenal fatigue or the usefulness of supplements to support adrenal function. (31) There is some speculation that stress levels may play a role in adrenal fatigue. Adrenal fatigue natural treatment may include the use of botanicals. An alternative medicine review suggests that botanicals may be useful in promoting recovery from stress, specifically adaptogens. The two best-known adaptogens are Panax ginseng and Eleutherococcus senticosus. Others include Withania somnifera, Glycyrrhiza species, and Rhodiola rose. Panax, Eleutherococcus, and Withania appear to exert effects primarily on the adrenal glands; whereas, Rhodiola appears to be primarily a central nervous system adaptogen. (30)

Natural treatment for fatigue

There is still no official recommendation for the treatment of various forms of fatigue. Natural treatment for fatigue is even less well studied. Normal fatigue can result from energy loss, low sugar levels, changes in your body’s metabolism, or changes in your body’s hormones. Abnormal fatigue can be pathological in nature, such as from inflammation, stress, side effects of treatments, changes in muscle, or changes in metabolism. Some natural medicines are often used as healthcare products such as ginseng, Cordyceps militaris, and Rhodiola Rosea. These are reported to have specific anti-fatigue effects with small toxic and side effects and rich pharmacological activities. (32)

Adrenal support formula

Decreased blood sugar levels, also known as hypoglycemia, play a role in adrenal health. As blood sugars decrease, cortisol levels rise in order to combat the effects. As such, an adrenal support formula that involves nutritional plans and goals may help in fighting against the body’s response to the effects. (2) One goal may be to reduce the consumption of simple carbohydrates and to have more small, frequent meals. This is believed to help maintain a more consistent blood sugar level. Another plan is to be aware of what is consumed. Although, restricting sodium intake is not necessary for adrenal gland support. (2)

Natural adrenal support

Managing cortisol levels is one way of regulating natural adrenal support. The body’s natural stress response system involves hormones and neurotransmitters that are important for its function. (2) Stimuli such as external or internal stressors result in a rise in cortisol levels and production in order to combat the effects on the body’s homeostasis. Homeostasis is the body’s affinity towards maintaining a stable environment. This relates to the body’s response to a fight or flight when stressful situations arise. This response involves multiple tissues working together. (2)

Stress and Adrenal Support

There is a correlation between stress and adrenal support. The adrenal glands are involved with the management of stress by releasing a hormone called cortisol. When stress levels are high, cortisol is released to help the body maintain homeostasis. Alternative and supplemental options for managing the adrenal gland response to varying stressors include mind-body intervention, nutrition, daily lifestyle habits, and supplements. (2) Establishing healthy and mindful self-care patterns are beneficial for stress management which can, in turn, support good adrenal health.

FAQ (Frequently Asked Questions)

What can damage the adrenal glands?

Damage to the adrenal glands can come suddenly stopping corticosteroids or being on corticosteroids for a long time. In addition, Tuberculosis, HIV, and tumors can lead to adrenal damage.

What helps low cortisol naturally?

Some natural ways to lower cortisol include exercise, vitamin C, fish oil, vitamin B complex, limiting alcohol intake, avoid caffeinated beverages, meditation, and going to bed consistently at the same time.

What are adrenal supplements good for?

Adrenal supplements can be used for multiple purposes such as fatigue, asthma, severe allergies, low adrenal function. In addition, it can help with psoriasis, rheumatoid arthritis, eczema, and more.

How can I improve my adrenal glands naturally?

One way to improve your adrenal glands naturally is to have a well-balanced diet and consume more vegetables to ensure an adequate amount of vitamins and minerals.

What are the best supplements for adrenal and cortisol?

The best supplements for adrenal fatigue include Licorice Root, Vitamin C, and Zinc. In addition, the best supplements for cortisol include fish oil and ashwagandha, an Asian herbal supplement.

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